NF EN ISO 23196, T90-900 (08/2023)

This document specifies the determination of biological equivalent concentrations (BEQ) from the results of in vitro bioassays which are based on the measurement of the effects produced on a biological process such as enzyme induction or cell growth. The concept described here can be used for any bioassay as long as its applicability has been demonstrated. To determine BEQ concentrations, the effect produced by a sample on a biological process, that is, the activity of the sample, is expressed as the concentration of a reference compound at which a equivalent effect is obtained on the process. The term “sample” as used in this document refers to environmental samples as well as specified mixtures and pure compounds used as objects of measurement in a bioassay. Biological equivalent concentrations can be determined for environmental water samples, extracts of environmental water samples, including tap water, or solutions of pure chemicals or mixtures of chemicals.
(Automatic translation from French)